Here's a few that I recently found interesting:
Tats for Tees - Interesting approach to reducing the concerns that people have about spending too much on a "want" (not a need) in a challenging economy.
3/50 Project - Powerful concept; Shared concern for 1000s of people; Explained in a simple way that many people can understand and take action.
Threadless - Redefining how a basic product (T-Shirts) is designed, forecasted, and manufactured. Embracing community on a whole new level.